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Use of Aviguard, Virginiamycin, or Bacitracin MD Against Clostridium perfringens-Associated Necrotizing Enteritis

Department of Avian Medicine, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602; Phone: (706) 542-1904; FAX: (706) 542-1573

Robert Froyman

Bayer AG, Business Group Animal Health, Biologicals R&D, Agricultural Centre Monheim, 50 Alfred-Nobel-Strasse, D-40780, Monheim, Germany

Beverly George

Colorado Quality Research, Inc., 400 E. County Road 72, Wellington, CO 80549

Mark A. Goodwin

Georgia Poultry Laboratory, P. O. Box 20, Oakwood, GA 30566

John Brown

Department of Medical Microbiology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602

Correspondence: Charles L. Hofacre

We have found that Aviguard is effective for reducing Clostridium perfringens-associated necrotic enteritis gross lesions that were induced by a necrotic enteritis infection model (NEIM). The present study compared the effects of Aviguard, Virginiamycin (Stafac-20), or bacitracin methylene disalicylate (BMD-50) against Clostridium perfringens-associated necrotizing enteritis in broiler chickens.

Male broiler chicks housed in the same environmentally controlled facility were given one of five treatments. The NEIM induced death, intestinal gross lesions, poor feed utilization, and lower body weight gain. Aviguard reduced mortality, gross lesions, and performance losses inflicted by the NEIM. Furthermore, Aviguard was superior to Virginiamycin and bacitracin MD for increasing broiler body weight gain and reducing feed consumption. Lastly, Aviguard was at least as effective as Virginiamycin and bacitracin MD in promoting feed efficiency.

Results from the present study are important because Aviguard can be considered a novel and effective nonantibiotic disease preventive in the face of Clostridium perfringens-associated necrotic enteritis challenge.

Key Words: Aviguard • bacitracin methylene disalicylate (BMD-50) • chickens • Clostridium perfringens • necrotic enteritis • Virginiamycin (Stafac-20)

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				C. L. Hofacre, G. F. Mathis, S. H. Miller, and M. W. LaVorgna Use of Bacitracin and Roxarsone to Reduce Salmonella Heidelberg Shedding Following a Necrotic Enteritis Challenge Model J. Appl. Poult. Res., January 1, 2007; 16(2): 275 - 279. [Abstract] [Full Text] [PDF]